Job Details
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FLSA Classification: Exempt/Salary
Schedule: 8:00 am - 5:00 pm; Monday - Friday
Department: Precision Medicine & Biomarkers
Reports to: Sr. Director Biomarkers
Supervisory responsibilities: No
Location: 2201 W Holcombe Blvd. Houston, TX 77030; On-site
Position Summary/objective:
Responsible for providing expertise for biomarker discovery and development, supporting assay development, validation and study execution.
Essential functions:
- Demonstrate experience in the delivery of biomarker assay development strategies, and have strong knowledge of biological systems, cellular functions and concepts in molecular biology/immunology to enable discovery and development objectives.
- Responsible for developing partnerships in a matrix environment, influencing project strategies, and providing expertise in technology development and implementation.
- Lead the development of sample preparation, separation and detection methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
- Generates study designs, study plans and technical reports as needed for different projects
- Responsible for maintaining regulatory compliance appropriate for clinical and preclinical study execution including all prescribed training as found in SOPs and work instructions.
- Possesses knowledge, training and understanding of GLP/GCP guidance for execution of preclinical and clinical studies supporting portfolio projects as applicable.
- Responsible for QC and peer review of raw data and results from colleagues and/or direct reports within the regulated group, as well as participation in internal and external audits providing required information to auditors as needed.
- Participate in continuous improvement of scientific and regulatory processes via update/creation of SOP's, design and implementation of laboratory and study-based processes, and development of best practices for bioanalytical data generation.
- Supports hands-on implementation as needed, trouble shooting, result evaluation and verbal/written reporting to required stakeholders in meetings.
- Partners across lines to integrate biomarker-based data into an overall understanding of drug MOA and efficacy.
- Mentor junior scientists/ research associates in biomarker strategy development, experimental protocol optimization, troubleshooting, data generation and analysis
Secondary functions: - Maintains and supports safe lab practices.
- May participate in CLIA/CAP activities
- Tracks the trends of an assay upon implementation
- Participates in database discussions
Competencies - Comfortable working at a global level in a highly matrixed environment. Excellent interdisciplinary and international communication and moderation skills.
- Knowledge of the principles of molecular biology, liquid biopsies, cell-based imaging analysis and cell biology/immunology.
- Knowledge of assay development
- Knowledge and experience of global regulatory requirements as well as industry guidance as they relate to GCLP.
- Excellent oral and written communication skills.
- Ability to coach and mentor colleagues in a matrix environment.
- Ability to work in teams.
Work environment: This position works in a typical office and/or clinical lab environment with moderate noise levels and uses phone, computer, office equipment and supplies on a regular basis. While performing the duties of this job, the employee is occasionally exposed to moving mechanical parts, fumes or airborne particles, pathogens and toxic or caustic chemicals. The employee is occasionally exposed to wet and/or humid conditions, risk of electrical shock, sharps, or cuts, while performing tests.
Physical demands: - Communicating Verbally - expressing or exchanging ideas by means of the spoken word to impart oral information to others to convey detailed spoken instructions or other workers accurately, loudly or quickly.
- Hearing - the ability to hear, understand, and distinguish speech and/or other sounds one-on-one, group or conference, telephone, and other sounds.
- Keyboarding - entering data or text into a computer or other machine by means of a keyboard. Devices include a traditional keyboard, 10 key-pad, touch screens and others.
- Lifting - raising or lowering an object (up to 25 lbs) from one level to another (includes upward pulling). Carrying is to transport an object - usually by holding it in the hands or arms but may occur on the shoulder.
- Near Visual Acuity - clarity of vision at approximately 20 inches or less (working with small objects, reading small print, including the use of computers).
- Pushing - Exerting force upon an object so that the object moves away from the object.
- Pulling - Exerting force upon an object so that the object moves toward the force.
- Sitting - remaining in a sitting position for at least 40% of the time.
- Standing/Walking - remain on one's feet in an upright position at a workstation.
- Stooping - occasional bending the body downward and forward by bending the spine at the waist - requiring full use of the lower extremities and back muscles.
Travel required: If needed for conferences or other sites
Required education and experience: - Ph.D. or other advanced degree in biology or other science/technology related discipline such as molecular biology, immunology, cell biology, or biochemistry.
- 3 to 5 years of extensive experience conducting analyses and research on various assay technologies and technical subjects.
Additional eligibility requirements: Knowledge in CLIA/CAP lab
Work authorization/security clearance requirements Legal eligibility to work in the United States is required. Immatics participates in E-Verify and all new employees will be subject to the Department of Homeland Security requirements for employment.
Affirmative Action/EEO statement Immatics is an equal opportunity employer. All employment decisions including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate on the basis of race, color, religion, national origin, ethnicity, marital status, age, physical or mental disability, medicalconditions, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law."
Other duties Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. This job description may not cover all duties that take place on a daily basis and may be changed as business needs change. Employee will be responsible for adapting and learning the duties as described above or as the new ones are introduced.