Job Details
Qilu Pharmaceuticals is a leading pharmaceutical and biopharmaceutical company in China, with 3 innovation centers in the US. We are seeking US-based experienced and self-motivated professionals to join our siRNA team. The successful candidate will be a key member of the drug discovery group and will lead efforts of advancing siRNA therapeutics to treat intractable diseases including liver diseases, neurological diseases and ocular diseases.
Primary Responsibilities
Responsible for nominating targets for diseases/indications for liver and extrahepatic tissues
Determine mechanism of action for drug targets; design and execute proof-of-concept studies to validate targets together with internal and/or external partners
Essential skills includes: RT-qPCR, ELISA, Western blot, cell culture, necropsy
Preferred skills: stem loop qPCR, co-immunoprecipitation, metabolic disease modeling, and hydrodynamic injections in mice
Perform preclinical candidate screening of siRNAs leading to lead compound selection via combined in vitro and in vivo assays, working with or supported by cross-disciplinary groups, including chemistry, bioassay, histology, and in vivo pharmacology, and/or CROs
Lead projects from inception to preclinical candidate nomination
Effectively manage multiple projects in parallel and deliver quality results within sensitive timelines
Comply with appropriate SOPs; train associates to meet requirements; present research findings to project teams, governance bodies, or external meetings
Effectively communicate across all organizational levels
Qualification
PhD in molecular biology, pharmacology, or related discipline with 1+ years of experience in pharmaceutical/biotech industry or 3+ years of experience as a post doc. The level of position will be determined by previous experience and achievements.
Ability to conduct in vitro screens (qPCR) in a 384 well format and identify leads as well as integrate counter screen data to select candidates
In vivo screening to utilizing a variety of routes of administration is desired (i.v., i.p., s.c., i.t., i.c.v.), and experience performing hydrodynamic injections is preferred.
Experience screening siRNA or ASOs is highly preferred; experience of gene/base editing is a plus
Track record of independent research and creativity, as demonstrated by quality publications and/or patents
Mechanistic understanding of metabolic diseases in liver highly preferred
Assay development to support preclinical and nonclinical efforts
Outstanding organizational and time management skills and must be a self-starter with the ability to thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment.
Excellent verbal and written communication skills