Job Details
Job Title: Head of Biology & Translational Science
Location: San Diego
Background
RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.
Summary
A key member of an entrepreneurial leadership team with a shared vision to build the leading radiopharmaceutical company. The ideal candidate will possess a deep knowledge of cancer biology and a record of achievement in oncology drug discovery and development. The role needs an accomplished, confident leader with hands-on experience of successfully advancing programs from discovery through lead optimization and IND submissions. The role requires an ability to lead and grow the in vitro/in vivo biology team in support of the pipeline growth while creating a results-oriented culture that emphasizes cooperation, teamwork, and respect. The role is expected to serve as the bridge between the discovery and clinical sciences for implementing a translational strategy for the programs in the development pipeline.
Job Responsibilities
Essential duties and responsibilities include the following. Other duties may be assigned.
- Provide strategic and operational leadership for the in vitro and in vivo biology teams.
- Build and grow the biology teams to support pipeline growth, foster a data driven, results-oriented culture and a high functioning team with strong emphasis on teamwork and cooperation. Identify and mentor promising scientists for leadership roles and create suitable career growth opportunities for aspiring scientists.
- Utilize a deep understanding of cancer biology and oncology drug development to lead the efforts on target selection and initiation of new RPT projects.
- Work in close collaboration with interdisciplinary teams to provide functional biology leadership to guide programs through lead identification/optimization phases.
- Develop preclinical GLP/non-GLP data packages to support regulatory submissions and clinical development.
- Work closely with clinical science, clinical operations, and medical affairs teams to develop a translational strategy to support clinical development programs.
- Build relationships with a network of KOLs/thought leaders and identify external resources for potential partnerships and collaborations.
- Author/review study reports and regulatory documentation, scientific presentations and publications manage external research collaborations.
- Create and manage department and project budgets, internal, external resources in support of corporate goals.
Education and Experience
- PhD in biology, pharmacology, or a related field
- 15+ years of leadership experience in pharmaceutical/biotech R&D environments.
- Demonstrated ability to build and lead high functioning discovery biology and translational teams and a track record of getting things done in small biotech settings.
- Deep understanding of cancer biology and oncology drug development and a demonstrated ability to advance programs from discovery through lead optimization and IND filings.
- Experience in leading targeted cancer therapies such as TRPs, ADCs, PDCs is highly desirable.
- Experience with analysis of preclinical and clinical datasets, biomarker technologies and an ability to implement precision medicine strategies in clinical settings.
- Solid understanding of FDA, EMA and relevant regulatory guidance for oncology drug development.
Skills and Qualifications
- Excellent written and oral communication skills and ability to work in a fast-paced, dynamic, and collaborative environment.
- High EQ, Strong interpersonal, organizational and communication skills and ability to motivate and drive productivity in small company environments.
- Ability to effectively partner with Clinical, regulatory, CMC and chemistry/DMPK teams.
- Ability to successfully establish and manage external collaborations including CROs and academic and industrial collaborations.