Job Details
Company Summary:
ParcelBio is an RNA therapeutics company that is developing novel technologies to unlock new mRNA-based medicines. Our proprietary ParcelOligo platform addresses existing limitations in mRNA delivery and expression to enable fully programmable mRNA medicines. ParcelBio was founded by leading innovators in RNA therapeutics, is advised by expert scientific and industry advisors, and is backed by a strong syndicate of investors including Y Combinator, General Catalyst, Metaplanet, and North South Ventures.
Position Summary:
ParcelBio is seeking a Senior Research Associate to lead the manufacturing of novel mRNA medicines. They will be responsible for producing high-quality mRNA for use in in vitro and in vivo studies to optimize the performance of the ParcelOligo platform. The ideal candidate will have hands-on experience with the synthesis, purification, and formulation of RNA therapeutics. We are looking for an enthusiastic and intellectually curious individual who enjoys a highly collaborative, fast-paced environment and is comfortable operating within the size and pace of a small start-up company.
Responsibilities:
- Manufacture mRNA therapeutics for platform and preclinical studies
- Perform analytical assessment of mRNA drug substance and drug product
- Contribute to the development and scale-up of processes for mRNA synthesis, purification, formulation, and analytics
- Maintain detailed SOPs and experimental records in an electronic lab notebook
- Communicate scientific results in internal and external meetings
Qualifications:
- M.S. with 3+ years of industry experience or B.S. with 5+ years experience in molecular biology, biochemistry, chemistry, or related discipline
- Experience working with in vitro transcribed RNA, including synthesis, purification (i.e., HPLC and TFF), and characterization (i.e., capillary electrophoresis); and/or experience in protein biochemistry (i.e., purification and characterization with chromatography-based methods) with an eagerness to work with RNA
- Prior experience with lipid nanoparticles a strong plus, including formulation (e.g., using microfluidics) and characterization (i.e., DLS and RiboGreen assays)
- Detail oriented in experimental planning, execution, analysis, and lab notebook documentation
- Organized and able to move multiple projects forward both independently and within a team
Compensation:
The expected annual salary range for this full-time position is $95,000-$115,00 plus eligibility for benefits and equity incentives. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.