Job Details
Who We Are:
At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.
What We Do:
Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie
About the Role:
As part of the Neuroimmunology Research Team, the individual will contribute to the assessment of novel therapeutic approaches to target autoimmunity and inflammation in neurodegenerative and movement disorders. We are seeking a highly motivated, dedicated and collaborative scientist with knowledge and expertise in cellular and molecular immunology, with experience in antibody/small molecule drug discovery. The successful candidate will work as part of a highly team-oriented and collaborative group. The focus of this position will be to support the progression of multiple drug discovery projects in the Neuroimmunology space, by independently designing, performing, and validating key in vitro cell-based functional assays. The candidate will also perform experiments to understand the mechanism of action of drug candidates, and present data to cross-functional teams.
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Your contributions (include, but are not limited to):
* Designing and performing experiments to support scientific activities and project goals
* Separation of human PBMC from whole blood, as well as the isolation of primary human leukocyte populations for downstream assays
* Isolation of immune cells from murine organs (spleen, etc)
* Maintain cell lines and primary cell cultures
* Perform immunological assays including lymphocyte proliferation, activation, cytokine secretion, and differentiation
* Perform basic molecular biology assays including mRNA isolation, Taqman qPCR, NanoString
* Flow cytometric analysis of immune cell subsets and analysis of data
* Perform immunoassays (MSD, ELISA, etc) for analysis of soluble proteins in cell supernatants/murine plasma
* Maintains and updates SOPs and electronic lab notebook, and writes data summaries for experiments conducted
* Present data and findings to cross-functional project teams
* Provides training and/or supervision to junior staff, as needed
* Other duties as assigned
Requirements:
* BS/BA degree and 3-5+ years of relevant experience, OR
* MS/MA degree and 2+ years of relevant experience
* PhD in immunology
* Experience with human PBMC isolation and cellular subset purification
* Expertise in cell culture and aseptic technique, involving both immortalized cell lines and primary human/murine cells
* Experience in immunoassays (ELISA, MSD, Western Blot, etc) and molecular biology techniques (mRNA isolation, qPCR)
* Experience with multicolor flow cytometric analysis, including spectral cytometry, is a plus
* Able to explain the process behind data generated and the implications of the results
* Strong knowledge of one or more scientific disciplines, especially immunology
* Strong knowledge of scientific principles, methods, and techniques, and demonstrated ability to work with a variety of laboratory equipment/tools
* Excellent communication, problem-solving, and analytical thinking skills
* Ability to work as part of a cross-functional team, and present data and concepts clearly and concisely
* Demonstrated ability to meet multiple deadlines with a high degree of accuracy and efficiency, and experience prioritizing multiple projects is a plus
Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.