Job Details
About Firefly Bio:
Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our state-of-the-art platform results in highly specific delivery of degraders to target tissue. Our mission is to realize the full potential of ADCs by unlocking new classes of payloads. Our company culture is built on the values of Focus, Integrity, Respect and Energy.
Position Summary:
The Sr. Scientist/Principal Scientist, Immunology will manage, plan and execute in vitro, ex vivo, and in vivo studies to evaluate novel drug conjugates for applications in inflammation, autoimmunity and other areas of unmet medical need. The position is lab-facing, on-site, and will report to the Head of Biology. Title and compensation package will be based on prior experience.
Responsibilities:
- Develop, perform, and optimize in vitro and ex vivo assays using human primary immune cells to evaluate novel payloads, antibodies, and drug conjugates
- Design, manage, and coordinate in vivo studies with CROs
- Establish strong in-house capabilities to perform primary immune cell experiments
- Collaborate cross-functionally with oncology, protein sciences and chemistry teams
- Participate in project teams and develop scientific presentations for internal and external audiences
Requirements and Experience:
- Ph.D in immunology, cell biology, or closely related field with 6-12 years of industry and/or post doc experience or a B.S. with a minimum of 10 years of industry experience
- Strong hands-on experience in managing, designing, and executing ex vivo and in vivo experiments to evaluate ADC, mAb, or small molecule therapeutics
- Significant immunology-based laboratory experience is required with the ability to perform flow cytometry on primary human and mouse immune cells
- Expertise in human B cell biology is highly preferred, but not mandatory
- Experience with isolating and culturing human and mouse primary immune cells, ELISA, and cytokine multiplex assays
- Demonstrated track record of scientific progress, including multiple, first author peer-reviewed publications
- Creativity and problem-solving skills paired with ability to excel in a highly collaborative environment
- Excellent oral and written communication and interpersonal skills
Benefits
Every team member is essential in shaping Firefly Bio s culture and science and for our success. We offer competitive compensation packages including stock options and the opportunity to be part of ground-breaking research. Firefly Bio is an equal opportunity employer and will consider all applicants for employment. Firefly Biologics does not discriminate based on race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity or any other reason prohibited by law in provision of employment opportunities and benefits.